A simple, sensitive, specific, spectrophotometric method was developed for the detection of Telmisartan (TLM) in bulk and in pharmaceutical formulations. The optimum conditions for the analysis of the drug were established. TLM was subjected to stress degradation under different conditions recommended by International Conference on Harmonization. The samples so generated were used for degradation studies using the developed method. The λmax of the TLM was found to be 297 nm. The method exhibited high sensitivity with linearity in 2 to 20 µg/ml range. The lower limit of detection and the limit of quantification were found to be 0.912 µg/ml and 4.467 µg/ml respectively. All calibration curves demonstrated a linear relationship between the absorbance and concentration with correlation coefficient higher than 0.99. The regression equation of the curve was Y = 0.055X. Precision of the method was found to be 80.054 ± 0.445 against the label claim of 80 mg. The percentage recovery was found to be 100.76 ± 0.960. The sample solution was stable up to 2 hours. Hence, it can be concluded that the proposed method will be suitable for the analysis of TLM in bulk and pharmaceutical formulations.
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